Référentiel des médicaments
Lopinavir
Lopinavir is a medicine in the class anti virals. It is used for hiv.
- Classe médicamenteuse: Anti Virals
- Indications: hiv
Dernière mise à jour Sources: US FDA label
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L'essentiel
- Classe médicamenteuse
- Anti Virals
- Interactions connues
- 274 (Contre-indiquée: 16 · Majeure: 115 · Modérée: 128 · Mineure: 15)
Indications
Mécanisme d'action
HIV-1 protease inhibitor; antiviral activity of the lopinavir/ritonavir combination is due to lopinavir, while ritonavir inhibits CYP3A metabolism of lopinavir and raises its plasma levels.
Posologie adulte habituelle (résumé de la notice)
HIV-1 infection: tablets 400/100 mg (two 200/50 mg tablets) twice daily, or oral solution 400/100 mg (5 mL) twice daily, with other antiretrovirals
Grossesse et allaitement
- Grossesse
- Safe Antiretroviral pregnancy registry data show no rise in birth defects. In pregnancy give 400/100 mg twice daily (once-daily dosing is not recommended) and avoid the oral solution, which contains about 42% alcohol and propylene glycol. Can be part of HIV treatment.
- Allaitement
- Safe Low levels pass into milk and reach some infants' blood; no infant harm clearly caused. US label: do not breastfeed (HIV transmission, resistance). Current US guidance supports breastfeeding only with sustained viral suppression after counselling; otherwise avoid.
Effets indésirables signalés
- Diarrhea
- Nausea
- Vomiting
- Abdominal pain
- Headache
- Asthenia
Contre-indications
- Hypersensitivity to any ingredient, including ritonavir (e.g., toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme).
- Co-administration with drugs highly dependent on CYP3A for clearance where elevated levels cause serious or life-threatening reactions.
- Co-administration with potent CYP3A inducers (loss of virologic response); Table 3 lists alfuzosin, rifampin, ergot derivatives, cisapride, St. John's Wort, lovastatin, simvastatin, sildenafil (Revatio), pimozide, triazolam, oral midazolam.
Précautions particulières
- CYP3A inhibition can raise levels of concomitant drugs, causing severe or fatal events; review all medications.
- Pancreatitis, including fatalities; suspend therapy as clinically appropriate if suspected.
- Hepatotoxicity: monitor liver function, especially with underlying hepatitis B or C or cirrhosis.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (274)
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
- Ergotamine + Lopinavir Contraindicated
- Flibanserin + Lopinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Ivabradine + Lopinavir Contraindicated
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Questions fréquentes
What is Lopinavir used for?
Lopinavir is a medicine in the class anti virals. It is used for HIV.
What side effects have been reported with Lopinavir?
Diarrhea, Nausea, Vomiting, Abdominal pain, Headache, Asthenia.
Can Lopinavir be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. Antiretroviral pregnancy registry data show no rise in birth defects. In pregnancy give 400/100 mg twice daily (once-daily dosing is not recommended) and avoid the oral solution, which contains about 42% alcohol and propylene glycol. Can be part of HIV treatment. Breastfeeding: Safe. Low levels pass into milk and reach some infants' blood; no infant harm clearly caused. US label: do not breastfeed (HIV transmission, resistance). Current US guidance supports breastfeeding only with sustained viral suppression after counselling; otherwise avoid.
What does Lopinavir interact with?
MediHelp lists 274 known interactions for Lopinavir. Contraindicated: 16 · Major: 115 · Moderate: 128 · Minor: 15. The most serious include Alfuzosin, Avanafil, Cisapride.
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