Référentiel des médicaments
Lubiprostone
Lubiprostone is a medicine in the class gastrointestinal tract. It is used for constipation.
- Classe médicamenteuse: Gastrointestinal Tract
- Indications: constipation
Dernière mise à jour
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
L'essentiel
- Classe médicamenteuse
- Gastrointestinal Tract
- Formes courantes
- gélule
- Dosages courants
- 24 mcg, 8 mcg
- Interactions connues
- 3 (Modérée: 2 · Mineure: 1)
- Noms commerciaux
- 12
- Pays et marchés
- 2
Indications
Mécanisme d'action
Locally acting chloride channel activator; increases intestinal fluid secretion and intestinal motility; acts locally at apical portion of intestine.
Posologie adulte habituelle (résumé de la notice)
Irritable Bowel Syndrome With Constipation: 8 mcg PO BID
Grossesse et allaitement
- Grossesse
- Unknown Limited human data. Little drug reaches the blood (one metabolite is measurable). No birth defects in rats or rabbits; fetal loss in guinea pigs was probably due to maternal toxicity. Use only if the benefit justifies the risk; osmotic laxatives or fibre are usual first choices.
- Allaitement
- Safe No human milk data; neither lubiprostone nor its active metabolite was found in rat milk, so little is expected in human milk. LactMed: not expected to harm the infant. If used, watch the infant for diarrhoea.
Effets indésirables signalés
- Headache
- Diarrhea
- Nausea
Contre-indications
- Hypersensitivity
- Mechanical GI obstruction
Précautions particulières
- Syncope and hypotension reported, some of which required hospitalization; most cases occurred in patients taking 24 mcg twice daily and some occurred within hours.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (3)
- Linaclotide + Lubiprostone Moderate
- Lubiprostone + Mosapride Moderate
- Deflazacort + Lubiprostone Minor
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Questions fréquentes
What is Lubiprostone used for?
Lubiprostone is a medicine in the class gastrointestinal tract. It is used for Constipation, Irritable bowel syndrome.
What side effects have been reported with Lubiprostone?
Headache, Diarrhea, Nausea.
Can Lubiprostone be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Limited human data. Little drug reaches the blood (one metabolite is measurable). No birth defects in rats or rabbits; fetal loss in guinea pigs was probably due to maternal toxicity. Use only if the benefit justifies the risk; osmotic laxatives or fibre are usual first choices. Breastfeeding: Safe. No human milk data; neither lubiprostone nor its active metabolite was found in rat milk, so little is expected in human milk. LactMed: not expected to harm the infant. If used, watch the infant for diarrhoea.
What does Lubiprostone interact with?
MediHelp lists 3 known interactions for Lubiprostone. Moderate: 2 · Minor: 1. The most serious include Linaclotide, Mosapride, Deflazacort.
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