Interactions médicamenteuses
Lubiprostone + Mosapride
Gravité: Modérée
Lubiprostone and Mosapride: moderate interaction.
Dernière mise à jour Sources: US FDA label
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
Résumé
Combining a 5-HT4 prokinetic with a chloride channel activator may increase diarrhea, nausea and fluid loss. There are no formal interaction studies, so the risk is predicted from pharmacology. Elderly patients and those prone to dehydration are most affected.
Ce que signifie cette interaction, en termes simples
Lubiprostone and Mosapride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lubiprostone belongs to Gastrointestinal Tract; Mosapride belongs to Gastrointestinal Tract.
Pourquoi elle survient
Pharmacodynamic: mosapride stimulates 5-HT4 receptors and increases gut motility, while lubiprostone activates ClC-2 chloride channels and increases intestinal fluid secretion.
Conduite à tenir
Optimise monotherapy before combining. If both are needed, start at low doses and ensure adequate hydration.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Réservé aux membres Pro+
Débloquer la page complète
Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Lubiprostone et Mosapride, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.
Références
Autres interactions de Mosapride
- Linaclotide + Mosapride Modérée
- Mosapride + Prucalopride Modérée
Autres interactions de Lubiprostone
- Linaclotide + Lubiprostone Modérée
- Deflazacort + Lubiprostone Mineure
Questions fréquentes
Can I take Lubiprostone with Mosapride?
MediHelp rates the interaction as moderate. Lubiprostone and Mosapride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a 5-HT4 prokinetic with a chloride channel activator may increase diarrhea, nausea and fluid loss. There are no formal interaction studies, so the risk is predicted from pharmacology. Elderly patients and those prone to dehydration are most affected.
How serious is the interaction between Lubiprostone and Mosapride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Optimise monotherapy before combining. If both are needed, start at low doses and ensure adequate hydration.
What other medicines interact with Mosapride?
MediHelp also lists interactions of Mosapride with, for example, Linaclotide, Prucalopride. The full list is on the Mosapride page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
