Référentiel des médicaments
Nelfinavir
Nelfinavir is a medicine in the class anti virals. It is used for hiv.
- Classe médicamenteuse: Anti Virals
- Indications: hiv
Dernière mise à jour Sources: US FDA label
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L'essentiel
- Classe médicamenteuse
- Anti Virals
- Formes courantes
- comprimé
- Interactions connues
- 286 (Contre-indiquée: 16 · Majeure: 80 · Modérée: 150 · Mineure: 40)
- Noms commerciaux
- 1
- Pays et marchés
- 1
Indications
Mécanisme d'action
Nelfinavir is an inhibitor of the HIV-1 protease.
Posologie adulte habituelle (résumé de la notice)
HIV-1 infection, adults and adolescents 13 years and older (tablets): 1250 mg twice daily or 750 mg three times daily, oral, with a meal, in combination with other antiretrovirals
Grossesse et allaitement
- Grossesse
- Unknown Consider alternative antiretrovirals during pregnancy because of hepatic adverse events and decreased exposure in 2nd/3rd trimesters; APR data show a birth defect rate of 3.9% with first trimester exposure. Clinical monitoring is recommended if used.
- Allaitement
- Unsafe Nelfinavir is present in low levels in human milk; mothers are instructed not to breastfeed because of HIV transmission and infant adverse reaction risks.
Effets indésirables signalés
- Diarrhea
- Nausea
- Rash
- Flatulence
- Leukopenia/neutropenia (pediatric)
- Anorexia (pediatric)
Contre-indications
- Coadministration with drugs highly dependent on CYP3A for clearance whose elevated concentrations cause serious or life-threatening events (e.g. alfuzosin, amiodarone, quinidine, lurasidone, pimozide, ergot derivatives, cisapride, lovastatin, simvastatin, sildenafil for PAH, triazolam, oral midazol…
- Rifampin and St. John's wort are contraindicated because they reduce nelfinavir concentrations, risking loss of effect and resistance.
Précautions particulières
- Drug interactions via CYP3A may cause serious adverse reactions or loss of efficacy; review concomitant medications.
- Should not be used in moderate or severe hepatic impairment.
- Oral powder contains phenylalanine (11.2 mg per gram), harmful in phenylketonuria.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (286)
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
- Ivabradine + Nelfinavir Contraindicated
- Lovastatin + Nelfinavir Contraindicated
- Lurasidone + Nelfinavir Contraindicated
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Questions fréquentes
What is Nelfinavir used for?
Nelfinavir is a medicine in the class anti virals. It is used for HIV.
What side effects have been reported with Nelfinavir?
Diarrhea, Nausea, Rash, Flatulence, Leukopenia/neutropenia (pediatric), Anorexia (pediatric).
Can Nelfinavir be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Consider alternative antiretrovirals during pregnancy because of hepatic adverse events and decreased exposure in 2nd/3rd trimesters; APR data show a birth defect rate of 3.9% with first trimester exposure. Clinical monitoring is recommended if used. Breastfeeding: Unsafe. Nelfinavir is present in low levels in human milk; mothers are instructed not to breastfeed because of HIV transmission and infant adverse reaction risks.
What does Nelfinavir interact with?
MediHelp lists 286 known interactions for Nelfinavir. Contraindicated: 16 · Major: 80 · Moderate: 150 · Minor: 40. The most serious include Alfuzosin, Avanafil, Dronedarone.
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