Référentiel des médicaments
Neratinib
Neratinib is a medicine in the class oncology. It is used for breast cancer.
- Classe médicamenteuse: Oncology
- Indications: breast cancer
Dernière mise à jour Sources: US FDA label
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L'essentiel
- Classe médicamenteuse
- Oncology
- Code ATC
- L01EH02
- Formes courantes
- comprimé
- Dosages courants
- 40 mg
- Interactions connues
- 59 (Majeure: 40 · Modérée: 14 · Mineure: 5)
- Noms commerciaux
- 2
- Pays et marchés
- 2
Indications
Mécanisme d'action
Intracellular kinase inhibitor that irreversibly binds EGFR, HER2 and HER4; reduces EGFR and HER2 autophosphorylation and downstream MAPK and AKT signaling.
Posologie adulte habituelle (résumé de la notice)
Extended adjuvant treatment of early-stage HER2-positive breast cancer: 240 mg (six tablets) orally once daily with food, continuously until disease recurrence or for up to one year.
Grossesse et allaitement
- Grossesse
- Unsafe Can cause fetal harm: no human data; in rabbits it caused abortion, embryo-fetal death and fetal abnormalities at exposures below those in patients. Test for pregnancy before starting; use effective contraception during treatment and for at least 1 month after (men: 3 months).
- Allaitement
- Unsafe No human milk data. LactMed: over 99% protein bound, so milk levels are likely low. US label: do not breastfeed during treatment and for at least 1 month after the last dose.
Effets indésirables signalés
- Diarrhea
- Nausea
- Abdominal pain
- Fatigue
- Vomiting
- Rash
Contre-indications
- None.
Précautions particulières
- Severe diarrhea with dehydration, hypotension and renal failure can occur; use loperamide prophylaxis or dose escalation, monitor and treat, interrupt and reduce dose as needed.
- Hepatotoxicity: measure total bilirubin, AST, ALT and alkaline phosphatase before treatment, monthly for 3 months, then every 3 months and as clinically indicated.
- Embryo-fetal toxicity: can cause fetal harm; use effective contraception.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (59)
- Amiodarone + Neratinib Major
- Amobarbital + Neratinib Major
- Aprepitant + Neratinib Major
- Armodafinil + Neratinib Major
- Bosentan + Neratinib Major
- Carbamazepine + Neratinib Major
- Cimetidine + Neratinib Major
- Clarithromycin + Neratinib Major
- Colchicine + Neratinib Major
- Crizotinib + Neratinib Major
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Questions fréquentes
What is Neratinib used for?
Neratinib is a medicine in the class oncology. It is used for Breast cancer.
What side effects have been reported with Neratinib?
Diarrhea, Nausea, Abdominal pain, Fatigue, Vomiting, Rash.
Can Neratinib be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm: no human data; in rabbits it caused abortion, embryo-fetal death and fetal abnormalities at exposures below those in patients. Test for pregnancy before starting; use effective contraception during treatment and for at least 1 month after (men: 3 months). Breastfeeding: Unsafe. No human milk data. LactMed: over 99% protein bound, so milk levels are likely low. US label: do not breastfeed during treatment and for at least 1 month after the last dose.
What does Neratinib interact with?
MediHelp lists 59 known interactions for Neratinib. Major: 40 · Moderate: 14 · Minor: 5. The most serious include Amiodarone, Amobarbital, Aprepitant.
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