Interactions médicamenteuses
Armodafinil + Neratinib
Gravité: Majeure
Armodafinil and Neratinib: major interaction.
Dernière mise à jour
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Résumé
Armodafinil may reduce neratinib exposure by inducing CYP3A4. Lower neratinib levels could reduce its efficacy in breast cancer treatment. Neratinib labeling advises against use with moderate or strong CYP3A4 inducers.
Ce que signifie cette interaction, en termes simples
Armodafinil and Neratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Armodafinil belongs to Central Nervous System; Neratinib belongs to Oncology.
Pourquoi elle survient
CYP3A4 induction by armodafinil enhances the metabolism of neratinib, a CYP3A4 substrate.
Conduite à tenir
Avoid the combination and use a non-inducing alternative to armodafinil. If it cannot be avoided, monitor for loss of tumor response.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Armodafinil
- Armodafinil + Avapritinib Majeure
- Armodafinil + Cyclosporine Majeure
- Armodafinil + Elacestrant Majeure
- Armodafinil + Elbasvir / grazoprevir Majeure
- Armodafinil + Entrectinib Majeure
- Armodafinil + Ethinylestradiol Majeure
Autres interactions de Neratinib
- Amiodarone + Neratinib Majeure
- Amobarbital + Neratinib Majeure
- Aprepitant + Neratinib Majeure
- Bosentan + Neratinib Majeure
- Carbamazepine + Neratinib Majeure
- Cimetidine + Neratinib Majeure
Questions fréquentes
Can I take Armodafinil with Neratinib?
MediHelp rates the interaction as major. Armodafinil and Neratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Armodafinil may reduce neratinib exposure by inducing CYP3A4. Lower neratinib levels could reduce its efficacy in breast cancer treatment. Neratinib labeling advises against use with moderate or strong CYP3A4 inducers.
How serious is the interaction between Armodafinil and Neratinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-inducing alternative to armodafinil. If it cannot be avoided, monitor for loss of tumor response.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Cyclosporine, Elacestrant. The full list is on the Armodafinil page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
