Référentiel des médicaments
Piperacillin-tazobactam
Piperacillin-tazobactam is a medicine in the class anti bacterial. It is used for female pelvic infections.
- Classe médicamenteuse: Anti Bacterial
- Indications: female pelvic infections
Dernière mise à jour
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L'essentiel
- Classe médicamenteuse
- Anti Bacterial
- Formes courantes
- injection, perfusion
- Dosages courants
- 4.5 g, 2.25 g, 2 g
- Interactions connues
- 54 (Majeure: 1 · Modérée: 32 · Mineure: 21)
- Noms commerciaux
- 30
- Pays et marchés
- 4
Indications
Mécanisme d'action
Antipseudomonal penicillin plus beta-lactamase inhibitor; inhibits biosynthesis of cell wall mucopeptide synthesis by binding to 1 or more of the penicillin-binding proteins and is effective during active-multiplication stage
Posologie adulte habituelle (résumé de la notice)
Intra-abdominal Infections: 3.375 g IV q6hr (totaling 13.5 g [12 g piperacillin/1.5 g tazobactam]) for 7-10 days
Mode de prise habituel
Penicillin antibiotics are taken by mouth or given by injection at regular intervals for a set number of days; the course should be completed even when symptoms improve early.
Grossesse et allaitement
- Grossesse
- Safe Both drugs cross the placenta; there are insufficient data to show a risk, and penicillins have long use in pregnancy without evidence of fetal harm. No malformations in rats or mice. Safe to use when indicated.
- Allaitement
- Safe Piperacillin passes into milk in low amounts, not expected to harm the infant; tazobactam is unstudied. LactMed: occasionally diarrhoea or thrush. Acceptable; breastfeeding can continue.
Effets indésirables signalés
- Headache
- Diarrhea
- Nausea
- Insomnia
- Constipation
- Fever
Contre-indications
- Allergy to penicillins, cephalosporins, imipenem, beta-lactamase inhibitors
Précautions particulières
- Prolonged use may result in fungal or bacterial superinfection
- Leukopenia/neutropenia associated with prolonged therapy; periodic assessment of hematopoietic function should be performed,
- Increased frequency of fever and rash reported in patients with cystic fibrosis receiving piperacillin
Anyone who has had an allergic reaction to a penicillin or another beta-lactam antibiotic must tell the prescriber before taking one. Severe or persistent diarrhoea during or after a course needs medical advice.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (54)
- Piperacillin-tazobactam + Vancomycin Major
- Amikacin + Piperacillin-tazobactam Moderate
- Antithrombin alfa + Piperacillin-tazobactam Moderate
- Antithrombin iii + Piperacillin-tazobactam Moderate
- Argatroban + Piperacillin-tazobactam Moderate
- Avelumab + Piperacillin-tazobactam Moderate
- Balstilimab + Piperacillin-tazobactam Moderate
- Bcg vaccine live + Piperacillin-tazobactam Moderate
- Bivalirudin + Piperacillin-tazobactam Moderate
- Camrelizumab + Piperacillin-tazobactam Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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Questions fréquentes
What is Piperacillin-tazobactam used for?
Piperacillin-tazobactam is a medicine in the class anti bacterial. It is used for Female pelvic infections, Intra-abdominal infections, Pneumonia, Sepsis, Skin infections.
What side effects have been reported with Piperacillin-tazobactam?
Headache, Diarrhea, Nausea, Insomnia, Constipation, Fever.
Can Piperacillin-tazobactam be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. Both drugs cross the placenta; there are insufficient data to show a risk, and penicillins have long use in pregnancy without evidence of fetal harm. No malformations in rats or mice. Safe to use when indicated. Breastfeeding: Safe. Piperacillin passes into milk in low amounts, not expected to harm the infant; tazobactam is unstudied. LactMed: occasionally diarrhoea or thrush. Acceptable; breastfeeding can continue.
What does Piperacillin-tazobactam interact with?
MediHelp lists 54 known interactions for Piperacillin-tazobactam. Major: 1 · Moderate: 32 · Minor: 21. The most serious include Vancomycin, Amikacin, Antithrombin alfa.
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