Référentiel des médicaments
Somapacitan
Somapacitan is a medicine in the class endocrine. It is used for growth failure.
- Classe médicamenteuse: Endocrine
- Indications: growth failure
Dernière mise à jour Sources: US FDA label
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L'essentiel
- Classe médicamenteuse
- Endocrine
- Code ATC
- H01AC07
- Formes courantes
- injection
- Interactions connues
- 101 (Modérée: 62 · Mineure: 39)
- Noms commerciaux
- 2
- Pays et marchés
- 2
Indications
Mécanisme d'action
Somapacitan-beco binds to a dimeric GH receptor on target cells, causing intracellular signal transduction. Some effects are mediated mainly by IGF-1 produced in the liver, others are direct effects of somapacitan-beco.
Posologie adulte habituelle (résumé de la notice)
Adult GHD: start 1.5 mg subcutaneously once weekly (treatment-naive or switching from daily GH); increase every 2 to 4 weeks by approximately 0.5 mg to 1.5 mg based on clinical response and IGF-1; maximum 8 mg once weekly
Grossesse et allaitement
- Grossesse
- Unknown No data for this long-acting growth hormone; decades of short-acting growth hormone use in pregnancy show no drug-related risk, and animals showed no birth defects. UK label: not recommended in pregnancy or without contraception. Growth hormone is usually stopped once pregnancy is confirmed.
- Allaitement
- Unknown No human data; it passes into rat milk. UK label: decide whether to stop breastfeeding or the drug. LactMed: a large, poorly absorbed molecule unlikely to reach the infant, but with no experience an alternative may be preferred with a newborn or preterm infant.
Effets indésirables signalés
- Nasopharyngitis
- Headache
- Pyrexia
- Pain in extremity
- Injection site reaction
- Cough
Contre-indications
- Acute critical illness after open-heart surgery, abdominal surgery or multiple accidental trauma, or acute respiratory failure
- Hypersensitivity to SOGROYA or any of its excipients
- Pediatric patients with closed epiphyses
Précautions particulières
- Increased mortality in acute critical illness
- Severe hypersensitivity including anaphylaxis and angioedema may occur
- Neoplasm risk: monitor patients with preexisting tumors; second neoplasm risk in childhood cancer survivors
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (101)
- Alogliptin + Somapacitan Moderate
- Alogliptin-metformin + Somapacitan Moderate
- Alogliptin-pioglitazone + Somapacitan Moderate
- Bazedoxifene-conjugated estrogens + Somapacitan Moderate
- Canagliflozin-metformin + Somapacitan Moderate
- Chlorpropamide + Somapacitan Moderate
- Cyclosporin + Somapacitan Moderate
- Dapagliflozin-metformin + Somapacitan Moderate
- Deflazacort + Somapacitan Moderate
- Desogestrel-ethinyl estradiol + Somapacitan Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
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Questions fréquentes
What is Somapacitan used for?
Somapacitan is a medicine in the class endocrine. It is used for Growth failure, Growth hormone deficiency.
What side effects have been reported with Somapacitan?
Nasopharyngitis, Headache, Pyrexia, Pain in extremity, Injection site reaction, Cough.
Can Somapacitan be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No data for this long-acting growth hormone; decades of short-acting growth hormone use in pregnancy show no drug-related risk, and animals showed no birth defects. UK label: not recommended in pregnancy or without contraception. Growth hormone is usually stopped once pregnancy is confirmed. Breastfeeding: Unknown. No human data; it passes into rat milk. UK label: decide whether to stop breastfeeding or the drug. LactMed: a large, poorly absorbed molecule unlikely to reach the infant, but with no experience an alternative may be preferred with a newborn or preterm infant.
What does Somapacitan interact with?
MediHelp lists 101 known interactions for Somapacitan. Moderate: 62 · Minor: 39. The most serious include Alogliptin, Alogliptin-metformin, Alogliptin-pioglitazone.
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