Référentiel des médicaments
Teduglutide
Teduglutide is a medicine in the class endocrine. It is used for short-bowel syndrome.
- Classe médicamenteuse: Endocrine
- Indications: short-bowel syndrome
Dernière mise à jour Sources: US FDA label
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L'essentiel
- Classe médicamenteuse
- Endocrine
- Code ATC
- A16AX08
- Formes courantes
- injection
- Dosages courants
- 5 mg/.5 ml
- Interactions connues
- 32 (Modérée: 22 · Mineure: 10)
- Noms commerciaux
- 3
- Pays et marchés
- 2
Indications
Mécanisme d'action
Teduglutide is an analog of human GLP-2. It binds GLP-2 receptors on intestinal enteroendocrine cells, subepithelial myofibroblasts and enteric neurons, causing local release of IGF-1, nitric oxide and keratinocyte growth factor.
Posologie adulte habituelle (résumé de la notice)
Short bowel syndrome dependent on parenteral support: 0.05 mg/kg once daily, subcutaneous injection only; not for intravenous or intramuscular use
Grossesse et allaitement
- Grossesse
- Unknown Limited case reports show no drug-associated risk of major birth defects or adverse outcomes; no embryo-fetal effects in rats and rabbits.
- Allaitement
- Unsafe No human milk data; teduglutide is present in rat milk. Breastfeeding is not recommended during treatment because of potential serious adverse reactions including tumorigenicity.
Effets indésirables signalés
- Abdominal pain
- Nausea
- Upper respiratory tract infection
- Abdominal distension
- Injection site reaction
- Vomiting
Précautions particulières
- Acceleration of neoplastic growth: potential for hyperplasia and neoplasia; polyps reported. Discontinue if GI malignancy develops. Colonoscopy and endoscopy needed before and during treatment.
- Intestinal obstruction has been reported; temporarily discontinue if it develops.
- Biliary and pancreatic disease (cholecystitis, cholangitis, cholelithiasis, pancreatitis): monitor bilirubin, alkaline phosphatase, lipase and amylase every 6 months.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (32)
- Chlordiazepoxide + Teduglutide Moderate
- Clonazepam + Teduglutide Moderate
- Colchicine + Teduglutide Moderate
- Cyclosporin + Teduglutide Moderate
- Digoxin + Teduglutide Moderate
- Ethosuximide + Teduglutide Moderate
- Flecainide + Teduglutide Moderate
- Fluphenazine + Teduglutide Moderate
- Haloperidol + Teduglutide Moderate
- Levothyroxine + Teduglutide Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
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Questions fréquentes
What is Teduglutide used for?
Teduglutide is a medicine in the class endocrine. It is used for Short-bowel syndrome.
What side effects have been reported with Teduglutide?
Abdominal pain, Nausea, Upper respiratory tract infection, Abdominal distension, Injection site reaction, Vomiting.
Can Teduglutide be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Limited case reports show no drug-associated risk of major birth defects or adverse outcomes; no embryo-fetal effects in rats and rabbits. Breastfeeding: Unsafe. No human milk data; teduglutide is present in rat milk. Breastfeeding is not recommended during treatment because of potential serious adverse reactions including tumorigenicity.
What does Teduglutide interact with?
MediHelp lists 32 known interactions for Teduglutide. Moderate: 22 · Minor: 10. The most serious include Chlordiazepoxide, Clonazepam, Colchicine.
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