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Interactions médicamenteuses

Levothyroxine + Teduglutide

Gravité: Modérée

Levothyroxine and Teduglutide: moderate interaction.

Dernière mise à jour

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Résumé

Teduglutide improves intestinal absorption of fluid and nutrients, which may increase absorption of oral levothyroxine. This could raise thyroid hormone exposure and cause signs of over-replacement in patients with short bowel syndrome.

Ce que signifie cette interaction, en termes simples

Levothyroxine and Teduglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Levothyroxine belongs to Endocrine; Teduglutide belongs to Endocrine.

Niveau de preuve: Moderate

Pourquoi elle survient

Teduglutide has intestinotrophic effects that enhance gastrointestinal absorption of orally administered drugs.

Conduite à tenir

Monitor TSH and free T4 after starting teduglutide and after dose changes. Reduce the levothyroxine dose if over-replacement develops.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Levothyroxine with Teduglutide?

MediHelp rates the interaction as moderate. Levothyroxine and Teduglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teduglutide improves intestinal absorption of fluid and nutrients, which may increase absorption of oral levothyroxine. This could raise thyroid hormone exposure and cause signs of over-replacement in patients with short bowel syndrome.

How serious is the interaction between Levothyroxine and Teduglutide?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor TSH and free T4 after starting teduglutide and after dose changes. Reduce the levothyroxine dose if over-replacement develops.

What other medicines interact with Levothyroxine?

MediHelp also lists interactions of Levothyroxine with, for example, Cholestyramine, Sodium iodide i-131, Tiratricol. The full list is on the Levothyroxine page.

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