Référentiel des médicaments
Thalidomide
Thalidomide is a medicine in the class miscellaneous. It is used for multiple myeloma.
- Classe médicamenteuse: Miscellaneous
- Indications: multiple myeloma
Dernière mise à jour Sources: US FDA label
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L'essentiel
- Classe médicamenteuse
- Miscellaneous
- Code ATC
- L04AX02
- Formes courantes
- gélule
- Interactions connues
- 41 (Majeure: 9 · Modérée: 29 · Mineure: 3)
- Noms commerciaux
- 3
- Pays et marchés
- 2
Indications
Mécanisme d'action
Mechanism not fully understood. Acts through cereblon, a component of a cullin ring E3 ubiquitin ligase complex; has immunomodulatory, anti-inflammatory and antiangiogenic properties.
Posologie adulte habituelle (résumé de la notice)
Newly diagnosed multiple myeloma (with dexamethasone): 200 mg orally once daily in 28-day cycles, with water, preferably at bedtime and at least 1 hour after the evening meal; dexamethasone 40 mg daily on days 1-4, 9-12 and 17-20 every 28 days
Grossesse et allaitement
- Grossesse
- Unsafe Contraindicated: a powerful human teratogen; even one dose can cause severe limb, ear, eye, heart and other defects, and about 40% of affected infants die at or soon after birth. Only within a pregnancy-prevention programme: contraception from 4 weeks before to 4 weeks after; men use condoms.
- Allaitement
- Unsafe No human milk data; high levels were found in rabbit milk. Because of possible serious reactions in the infant, do not breastfeed during treatment (US label); LactMed: the manufacturer and professional guidelines recommend against breastfeeding.
Effets indésirables signalés
- Fatigue
- Hypocalcemia
- Edema
- Constipation
- Sensory neuropathy
- Dyspnea
Mises en garde encadrées
- Embryo-fetal toxicity: can cause severe birth defects or embryo-fetal death, even with a single capsule. Must never be used by females who are or could become pregnant. Exclude pregnancy before treatment and use two reliable contraception methods. Available only through the THALOMID REMS program.
Contre-indications
- Pregnancy
- Demonstrated hypersensitivity to the drug or its components
Précautions particulières
- Venous and arterial thromboembolism, including ischemic heart disease, MI and stroke, with dexamethasone
- Increased mortality when pembrolizumab is added to a thalidomide analogue plus dexamethasone in MM; not recommended outside controlled trials
- Frequent drowsiness and somnolence; avoid hazardous tasks and other sedating drugs
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (41)
- Bortezomib + Thalidomide Major
- Carbamazepine + Thalidomide Major
- Griseofulvin + Thalidomide Major
- Modafinil + Thalidomide Major
- Nivolumab + Thalidomide Major
- Phenytoin + Thalidomide Major
- Rifabutin + Thalidomide Major
- Rifampicin + Thalidomide Major
- Thalidomide + Vincristine Major
- Amiodarone + Thalidomide Moderate
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- Renal and hepatic dose adjustments
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Questions fréquentes
What is Thalidomide used for?
Thalidomide is a medicine in the class miscellaneous. It is used for Multiple myeloma.
What side effects have been reported with Thalidomide?
Fatigue, Hypocalcemia, Edema, Constipation, Sensory neuropathy, Dyspnea. Serious warning: Embryo-fetal toxicity: can cause severe birth defects or embryo-fetal death, even with a single capsule.
Can Thalidomide be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Contraindicated: a powerful human teratogen; even one dose can cause severe limb, ear, eye, heart and other defects, and about 40% of affected infants die at or soon after birth. Only within a pregnancy-prevention programme: contraception from 4 weeks before to 4 weeks after; men use condoms. Breastfeeding: Unsafe. No human milk data; high levels were found in rabbit milk. Because of possible serious reactions in the infant, do not breastfeed during treatment (US label); LactMed: the manufacturer and professional guidelines recommend against breastfeeding.
What does Thalidomide interact with?
MediHelp lists 41 known interactions for Thalidomide. Major: 9 · Moderate: 29 · Minor: 3. The most serious include Bortezomib, Carbamazepine, Griseofulvin.
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