Interactions médicamenteuses
Nivolumab + Thalidomide
Gravité: Majeure
Nivolumab and Thalidomide: major interaction.
Dernière mise à jour Sources: UK SmPC
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Résumé
Thalidomide is an immunomodulator, and concurrent use with PD-1 antibodies in multiple myeloma has been linked to excess mortality in trials of pembrolizumab combinations. Nivolumab is expected to share this class risk, though direct evidence is limited. Outside a clinical trial the combination offers no proven benefit.
Ce que signifie cette interaction, en termes simples
Nivolumab and Thalidomide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nivolumab belongs to Oncology; Thalidomide belongs to Miscellaneous.
Pourquoi elle survient
Combined immune modulation with PD-1 blockade and thalidomide analogs; the mechanism of excess harm is not fully established.
Conduite à tenir
Avoid combining nivolumab with thalidomide or related agents in multiple myeloma outside a clinical trial. If used, monitor closely for immune-related adverse events and infections.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Références
- OPDIVO 10 mg/mL concentrate for solution for infusion - SmPC sections 4.3/4.5 (class statement: other immunosuppressants; "The use of systemic corticosteroids and other immunosuppressants at baseline, before starting nivolumab, should be avoided because of their potential interferen") — electronic medicines compendium (UK SmPC)
Autres interactions de Nivolumab
- Dexamethasone-tobramycin + Nivolumab Modérée
- Dexamethasone + Nivolumab Modérée
- Efgartigimod / hyaluronidase sc + Nivolumab Modérée
- Efgartigimod alfa + Nivolumab Modérée
- Nivolumab + Ponesimod Modérée
- Nivolumab + Rozanolixizumab Modérée
Autres interactions de Thalidomide
- Bortezomib + Thalidomide Majeure
- Carbamazepine + Thalidomide Majeure
- Griseofulvin + Thalidomide Majeure
- Modafinil + Thalidomide Majeure
- Phenytoin + Thalidomide Majeure
- Rifabutin + Thalidomide Majeure
Questions fréquentes
Can I take Nivolumab with Thalidomide?
MediHelp rates the interaction as major. Nivolumab and Thalidomide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Thalidomide is an immunomodulator, and concurrent use with PD-1 antibodies in multiple myeloma has been linked to excess mortality in trials of pembrolizumab combinations. Nivolumab is expected to share this class risk, though direct evidence is limited. Outside a clinical trial the combination offers no proven benefit.
How serious is the interaction between Nivolumab and Thalidomide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining nivolumab with thalidomide or related agents in multiple myeloma outside a clinical trial. If used, monitor closely for immune-related adverse events and infections.
What other medicines interact with Nivolumab?
MediHelp also lists interactions of Nivolumab with, for example, Dexamethasone-tobramycin, Dexamethasone, Efgartigimod / hyaluronidase sc. The full list is on the Nivolumab page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
