Référentiel des médicaments
Tretinoin
Tretinoin is a medicine in the class dermatology. It is used for acne.
- Classe médicamenteuse: Dermatology
- Indications: acne
Dernière mise à jour
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L'essentiel
- Classe médicamenteuse
- Dermatology
- Formes courantes
- crème, gel, gélule, solution, lotion
- Dosages courants
- 0.05%, 0.025%, 10 mg
- Interactions connues
- 65 (Majeure: 7 · Modérée: 20 · Mineure: 38)
- Noms commerciaux
- 28
- Pays et marchés
- 4
Indications
Mécanisme d'action
Retinoid, induces differentiation and decreased proliferation of APL cells; produces an initial maturation of promyelocytes, followed by a repopulation of the bone marrow and peripheral blood by normal polyclonal hematopoietic cells in patients achieving complete remission
Posologie adulte habituelle (résumé de la notice)
Acute Promyelocytic Leukemia: 45 mg/m²/day PO divided q12hr, Discontinue 30 days after complete remission or 90 days after start of treatment (whichever comes first)
Grossesse et allaitement
- Grossesse
- Unsafe Oral capsules (for leukaemia): retinoid that causes severe birth defects and miscarriage; pregnancy test before, and two contraception methods during and for 1 month after. Creams/gels: little is absorbed, but retinoid labels in the EU/UK advise against use in pregnancy; stop if pregnant.
- Allaitement
- Unsafe Oral capsules: not studied; do not breastfeed during treatment and for 1 week after the last dose. Creams and gels: poorly absorbed, so LactMed considers them low risk; do not apply to the nipple or areola and keep the baby's skin off treated areas.
Effets indésirables signalés
- Headache
- Pruritus
- Bone pain
- Erythema
- Fever
- Excessive dryness
Précautions particulières
- Systemic: Leukocytosis may occur
- Systemic: Do not coadminister with other retinoids or in combination with vitamin A because symptoms of hypervitaminosis A
- Systemic: There is risk of thrombosis (both venous and arterial) which may involve any organ system, during first month of treatment
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (65)
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Omadacycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
- Tranexamic acid + Tretinoin Major
- Aminolevulinic acid + Tretinoin Moderate
- Chlorpromazine + Tretinoin Moderate
- Ciprofloxacin + Tretinoin Moderate
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- Paediatric dosing
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Questions fréquentes
What is Tretinoin used for?
Tretinoin is a medicine in the class dermatology. It is used for Acne, Leukemia, Melasma, Wrinkles.
What side effects have been reported with Tretinoin?
Headache, Pruritus, Bone pain, Erythema, Fever, Excessive dryness.
Can Tretinoin be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Oral capsules (for leukaemia): retinoid that causes severe birth defects and miscarriage; pregnancy test before, and two contraception methods during and for 1 month after. Creams/gels: little is absorbed, but retinoid labels in the EU/UK advise against use in pregnancy; stop if pregnant. Breastfeeding: Unsafe. Oral capsules: not studied; do not breastfeed during treatment and for 1 week after the last dose. Creams and gels: poorly absorbed, so LactMed considers them low risk; do not apply to the nipple or areola and keep the baby's skin off treated areas.
What does Tretinoin interact with?
MediHelp lists 65 known interactions for Tretinoin. Major: 7 · Moderate: 20 · Minor: 38. The most serious include Doxycycline, Minocycline, Omadacycline.
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