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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Aminolevulinic acid + Tretinoin

Gravité: Modérée

Aminolevulinic acid and Tretinoin: moderate interaction.

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Résumé

Oral aminolevulinic acid causes protoporphyrin IX accumulation and photosensitivity. Tretinoin can increase skin sensitivity to light, so phototoxic reactions such as severe sunburn may be worse. Systemic tretinoin is the main concern; topical use adds little.

Ce que signifie cette interaction, en termes simples

Aminolevulinic acid and Tretinoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Aminolevulinic acid belongs to Miscellaneous; Tretinoin belongs to Dermatology.

Niveau de preuve: Low

Pourquoi elle survient

Additive photosensitizing effects from two agents that increase the skin's reactivity to light.

Conduite à tenir

Counsel strict photoprotection and avoid sun and bright light exposure after aminolevulinic acid for the period specified in labeling. Avoid giving other photosensitizers perioperatively around dosing.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Aminolevulinic acid with Tretinoin?

MediHelp rates the interaction as moderate. Aminolevulinic acid and Tretinoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral aminolevulinic acid causes protoporphyrin IX accumulation and photosensitivity. Tretinoin can increase skin sensitivity to light, so phototoxic reactions such as severe sunburn may be worse. Systemic tretinoin is the main concern; topical use adds little.

How serious is the interaction between Aminolevulinic acid and Tretinoin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel strict photoprotection and avoid sun and bright light exposure after aminolevulinic acid for the period specified in labeling. Avoid giving other photosensitizers perioperatively around dosing.

What other medicines interact with Tretinoin?

MediHelp also lists interactions of Tretinoin with, for example, Doxycycline, Minocycline, Omadacycline. The full list is on the Tretinoin page.

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