Référentiel des médicaments
Trientine
Trientine is a medicine in the class miscellaneous. It is used for wilson's disease.
- Classe médicamenteuse: Miscellaneous
- Indications: wilson's disease
Dernière mise à jour Sources: US FDA label
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L'essentiel
- Classe médicamenteuse
- Miscellaneous
- Formes courantes
- comprimé, gélule
- Dosages courants
- 250 mg, 300 mg
- Interactions connues
- 22 (Modérée: 9 · Mineure: 13)
- Noms commerciaux
- 4
- Pays et marchés
- 2
Indications
Mécanisme d'action
Copper chelator that removes absorbed copper by forming a stable complex eliminated in urine; it also chelates copper in the intestinal tract, reducing copper absorption.
Posologie adulte habituelle (résumé de la notice)
Stable Wilson's disease (de-coppered, penicillamine-tolerant): starting total daily dose 300 mg up to 3,000 mg orally in divided doses, two times daily; adjust by clinical assessment and copper monitoring; maximum 3,000 mg/day
Grossesse et allaitement
- Grossesse
- Unknown Published data and decades of use have not identified drug-associated risks for birth defects or miscarriage, but animal studies showed embryo-fetal loss and fetal abnormalities. Monitor copper throughout pregnancy and use the minimum effective dose.
- Allaitement
- Unknown Data on detection in breastmilk are inconsistent; no adverse effects in breastfed infants reported. Weigh benefits of breastfeeding against maternal need.
Effets indésirables signalés
- Abdominal pain
- Change of bowel habits
- Rash
- Alopecia
- Mood swings
Contre-indications
- Hypersensitivity to trientine or any excipient in CUVRIOR.
Précautions particulières
- Clinical symptoms, including neurological deterioration, may worsen at the start of therapy due to copper mobilization.
- Copper deficiency may develop; monitor closely, particularly in pregnancy.
- Iron deficiency may develop, especially in menstruating or pregnant women; iron may be given in short courses at least 2 hours apart from CUVRIOR.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (22)
- Calcium + Trientine Moderate
- Carbonyl iron + Trientine Moderate
- Copper + Trientine Moderate
- Ferrous fumarate + Trientine Moderate
- Ferrous gluconate + Trientine Moderate
- Ferrous sulfate + Trientine Moderate
- Iron + Trientine Moderate
- Magnesium + Trientine Moderate
- Trientine + Zinc Moderate
- Acetazolamide + Trientine Minor
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Questions fréquentes
What is Trientine used for?
Trientine is a medicine in the class miscellaneous. It is used for Wilson's disease.
What side effects have been reported with Trientine?
Abdominal pain, Change of bowel habits, Rash, Alopecia, Mood swings.
Can Trientine be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Published data and decades of use have not identified drug-associated risks for birth defects or miscarriage, but animal studies showed embryo-fetal loss and fetal abnormalities. Monitor copper throughout pregnancy and use the minimum effective dose. Breastfeeding: Unknown. Data on detection in breastmilk are inconsistent; no adverse effects in breastfed infants reported. Weigh benefits of breastfeeding against maternal need.
What does Trientine interact with?
MediHelp lists 22 known interactions for Trientine. Moderate: 9 · Minor: 13. The most serious include Calcium, Carbonyl iron, Copper.
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