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Interactions médicamenteuses

Aceclofenac + Probenecid

Gravité: Modérée

Aceclofenac and Probenecid: moderate interaction.

Dernière mise à jour

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Résumé

Probenecid inhibits renal organic anion transport and can raise NSAID concentrations, including those of aceclofenac and its metabolites. This may increase NSAID adverse effects such as gastrointestinal and renal toxicity.

Ce que signifie cette interaction, en termes simples

Aceclofenac and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Aceclofenac belongs to Musculoskeletal; Probenecid belongs to Genitourinary.

Niveau de preuve: Moderate

Pourquoi elle survient

Probenecid inhibits OAT-mediated renal tubular secretion of aceclofenac and its metabolites.

Conduite à tenir

Use the lowest effective aceclofenac dose and monitor for GI bleeding and renal function. Reduce the NSAID dose if adverse effects appear.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Aceclofenac with Probenecid?

MediHelp rates the interaction as moderate. Aceclofenac and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid inhibits renal organic anion transport and can raise NSAID concentrations, including those of aceclofenac and its metabolites. This may increase NSAID adverse effects such as gastrointestinal and renal toxicity.

How serious is the interaction between Aceclofenac and Probenecid?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective aceclofenac dose and monitor for GI bleeding and renal function. Reduce the NSAID dose if adverse effects appear.

What other medicines interact with Probenecid?

MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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