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Interactions médicamenteuses

Aceclofenac + Sulphasalazine

Gravité: Modérée

Aceclofenac and Sulphasalazine: moderate interaction.

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Résumé

Aceclofenac is an NSAID and sulfasalazine contains a salicylate-related moiety, so combined use may add to gastrointestinal irritation, renal effects and bleeding tendency. Clinically significant harm is uncommon but possible in at-risk patients.

Ce que signifie cette interaction, en termes simples

Aceclofenac and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Aceclofenac belongs to Musculoskeletal; Sulphasalazine belongs to Gastrointestinal Tract.

Niveau de preuve: Low

Pourquoi elle survient

Additive NSAID effects on platelet function, gastric mucosa and renal prostaglandins.

Conduite à tenir

Use the lowest effective NSAID dose and monitor for gastrointestinal bleeding, renal function and blood counts. Consider gastroprotection in high-risk patients.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Aceclofenac with Sulphasalazine?

MediHelp rates the interaction as moderate. Aceclofenac and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aceclofenac is an NSAID and sulfasalazine contains a salicylate-related moiety, so combined use may add to gastrointestinal irritation, renal effects and bleeding tendency. Clinically significant harm is uncommon but possible in at-risk patients.

How serious is the interaction between Aceclofenac and Sulphasalazine?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose and monitor for gastrointestinal bleeding, renal function and blood counts. Consider gastroprotection in high-risk patients.

What other medicines interact with Sulphasalazine?

MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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