Interactions médicamenteuses
Pexidartinib + Sulphasalazine
Gravité: Majeure
Pexidartinib and Sulphasalazine: major interaction.
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Résumé
Pexidartinib carries a boxed warning for serious and potentially fatal liver injury, and sulfasalazine can also cause hepatotoxicity. Using both increases the chance of liver injury.
Ce que signifie cette interaction, en termes simples
Pexidartinib and Sulphasalazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pexidartinib belongs to Oncology; Sulphasalazine belongs to Gastrointestinal Tract.
Pourquoi elle survient
Additive hepatotoxicity from two agents that can each cause liver injury.
Conduite à tenir
Avoid the combination if possible. If both are needed, check liver tests at baseline and frequently, and stop treatment if liver injury develops.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Sulphasalazine
- Deferiprone + Sulphasalazine Majeure
- Sepiapterin + Sulphasalazine Majeure
- Acalabrutinib + Sulphasalazine Modérée
- Aceclofenac + Sulphasalazine Modérée
- Acetazolamide + Sulphasalazine Modérée
- Asciminib + Sulphasalazine Modérée
Autres interactions de Pexidartinib
- Allopurinol + Pexidartinib Majeure
- Amiodarone + Pexidartinib Majeure
- Amobarbital + Pexidartinib Majeure
- Amoxicillin-clavulanic acid + Pexidartinib Majeure
- Apalutamide + Pexidartinib Majeure
- Aprepitant + Pexidartinib Majeure
Questions fréquentes
Can I take Pexidartinib with Sulphasalazine?
MediHelp rates the interaction as major. Pexidartinib and Sulphasalazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pexidartinib carries a boxed warning for serious and potentially fatal liver injury, and sulfasalazine can also cause hepatotoxicity. Using both increases the chance of liver injury.
How serious is the interaction between Pexidartinib and Sulphasalazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If both are needed, check liver tests at baseline and frequently, and stop treatment if liver injury develops.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Sepiapterin, Acalabrutinib. The full list is on the Sulphasalazine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
