Interactions médicamenteuses
Acetylsalicylic acid + Bismuth subsalicylate
Gravité: Modérée
Acetylsalicylic acid and Bismuth subsalicylate: moderate interaction.
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Résumé
Bismuth subsalicylate is hydrolysed to release salicylate, so taking it with aspirin adds to the total salicylate load. This can raise the risk of salicylate toxicity such as tinnitus and gastrointestinal bleeding, especially with repeated or high dosing.
Ce que signifie cette interaction, en termes simples
Acetylsalicylic acid and Bismuth subsalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Bismuth subsalicylate belongs to Gastrointestinal Tract.
Pourquoi elle survient
Additive salicylate exposure and additive antiplatelet and gastrointestinal mucosal effects.
Conduite à tenir
Avoid routine concurrent use of bismuth subsalicylate with analgesic-dose aspirin and limit duration. Monitor for tinnitus, GI bleeding and bruising, particularly in older adults and those on anticoagulants.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contre-indiquée
- Acetylsalicylic acid + Ketorolac intranasal Contre-indiquée
- Abciximab + Acetylsalicylic acid Majeure
- Acemetacin + Acetylsalicylic acid Majeure
- Acetazolamide + Acetylsalicylic acid Majeure
- Acetylsalicylic acid + Alteplase Majeure
Autres interactions de Bismuth subsalicylate
Questions fréquentes
Can I take Acetylsalicylic acid with Bismuth subsalicylate?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Bismuth subsalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bismuth subsalicylate is hydrolysed to release salicylate, so taking it with aspirin adds to the total salicylate load. This can raise the risk of salicylate toxicity such as tinnitus and gastrointestinal bleeding, especially with repeated or high dosing.
How serious is the interaction between Acetylsalicylic acid and Bismuth subsalicylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine concurrent use of bismuth subsalicylate with analgesic-dose aspirin and limit duration. Monitor for tinnitus, GI bleeding and bruising, particularly in older adults and those on anticoagulants.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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