Interactions médicamenteuses
Bismuth subsalicylate + Dichlorphenamide
Gravité: Majeure
Bismuth subsalicylate and Dichlorphenamide: major interaction.
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Résumé
Bismuth subsalicylate is hydrolysed to salicylate, and dichlorphenamide is a carbonic anhydrase inhibitor; with salicylates it can accumulate salicylate and worsen metabolic acidosis. Tachypnoea, lethargy and coma have been reported with high-dose aspirin.
Ce que signifie cette interaction, en termes simples
Bismuth subsalicylate and Dichlorphenamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bismuth subsalicylate belongs to Gastrointestinal Tract; Dichlorphenamide belongs to Miscellaneous.
Pourquoi elle survient
Carbonic anhydrase inhibition causes metabolic acidosis and reduced salicylate renal clearance, raising salicylate levels
Conduite à tenir
Avoid bismuth subsalicylate during dichlorphenamide therapy; if salicylate is needed use lowest dose and monitor acid-base status and symptoms of salicylism.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Bismuth subsalicylate
- Bismuth subsalicylate + Warfarin Majeure
- Acetylsalicylic acid + Bismuth subsalicylate Modérée
- Amlodipine-benazepril + Bismuth subsalicylate Modérée
- Aspirin / citric acid / sodium bicarbonate + Bismuth subsalicylate Modérée
- Aspirin rectal + Bismuth subsalicylate Modérée
- Aspirin + Bismuth subsalicylate Modérée
Autres interactions de Dichlorphenamide
Questions fréquentes
Can I take Bismuth subsalicylate with Dichlorphenamide?
MediHelp rates the interaction as major. Bismuth subsalicylate and Dichlorphenamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bismuth subsalicylate is hydrolysed to salicylate, and dichlorphenamide is a carbonic anhydrase inhibitor; with salicylates it can accumulate salicylate and worsen metabolic acidosis. Tachypnoea, lethargy and coma have been reported with high-dose aspirin.
How serious is the interaction between Bismuth subsalicylate and Dichlorphenamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid bismuth subsalicylate during dichlorphenamide therapy; if salicylate is needed use lowest dose and monitor acid-base status and symptoms of salicylism.
What other medicines interact with Bismuth subsalicylate?
MediHelp also lists interactions of Bismuth subsalicylate with, for example, Warfarin, Acetylsalicylic acid, Amlodipine-benazepril. The full list is on the Bismuth subsalicylate page.
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