Interactions médicamenteuses
Adenovirus types 4 and 7 live + Doxorubicin
Gravité: Majeure
Adenovirus types 4 and 7 live and Doxorubicin: major interaction.
Dernière mise à jour
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Résumé
Doxorubicin causes myelosuppression and immunosuppression, which can blunt the response to the live oral adenovirus vaccine. The attenuated virus may also replicate more extensively in an immunocompromised patient, raising the risk of vaccine-related infection.
Ce que signifie cette interaction, en termes simples
Adenovirus types 4 and 7 live and Doxorubicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Cytotoxic immunosuppression impairs vaccine immune response and permits uncontrolled replication of the live attenuated virus.
Conduite à tenir
Avoid live vaccines during chemotherapy and for at least 3 months after it ends, or until immune recovery is confirmed. Use non-live vaccines where an alternative exists.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Doxorubicin
- Belatacept + Doxorubicin Majeure
- Cobicistat + Doxorubicin Majeure
- Cyclophosphamide + Doxorubicin Majeure
- Cyclosporine + Doxorubicin Majeure
- Cyclosporin + Doxorubicin Majeure
- Deferiprone + Doxorubicin Majeure
Questions fréquentes
Can I take Adenovirus types 4 and 7 live with Doxorubicin?
MediHelp rates the interaction as major. Adenovirus types 4 and 7 live and Doxorubicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Doxorubicin causes myelosuppression and immunosuppression, which can blunt the response to the live oral adenovirus vaccine. The attenuated virus may also replicate more extensively in an immunocompromised patient, raising the risk of vaccine-related infection.
How serious is the interaction between Adenovirus types 4 and 7 live and Doxorubicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during chemotherapy and for at least 3 months after it ends, or until immune recovery is confirmed. Use non-live vaccines where an alternative exists.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Belatacept, Cobicistat, Cyclophosphamide. The full list is on the Doxorubicin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
