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Interactions médicamenteuses

Deferiprone + Doxorubicin

Gravité: Majeure

Deferiprone and Doxorubicin: major interaction.

Dernière mise à jour

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Résumé

Deferiprone can cause agranulocytosis and neutropenia, and doxorubicin is myelosuppressive. Combined use increases the risk of severe neutropenia and serious infection.

Ce que signifie cette interaction, en termes simples

Deferiprone and Doxorubicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Deferiprone belongs to Miscellaneous; Doxorubicin belongs to Oncology.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive myelosuppressive toxicity on neutrophil lineage.

Conduite à tenir

Avoid combining where possible. If necessary, monitor absolute neutrophil count more often and interrupt deferiprone if neutropenia develops.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Deferiprone with Doxorubicin?

MediHelp rates the interaction as major. Deferiprone and Doxorubicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Deferiprone can cause agranulocytosis and neutropenia, and doxorubicin is myelosuppressive. Combined use increases the risk of severe neutropenia and serious infection.

How serious is the interaction between Deferiprone and Doxorubicin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible. If necessary, monitor absolute neutrophil count more often and interrupt deferiprone if neutropenia develops.

What other medicines interact with Doxorubicin?

MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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