Interactions médicamenteuses
Adenovirus types 4 and 7 live + Fluorouracil
Gravité: Majeure
Adenovirus types 4 and 7 live and Fluorouracil: major interaction.
Dernière mise à jour
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Résumé
Fluorouracil causes myelosuppression and immunosuppression, so a live oral adenovirus vaccine may replicate excessively and cause disease. The vaccine response may also be blunted.
Ce que signifie cette interaction, en termes simples
Adenovirus types 4 and 7 live and Fluorouracil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Cytotoxic immunosuppression impairs control of live-attenuated virus and reduces vaccine immunogenicity.
Conduite à tenir
Do not give the live vaccine during chemotherapy; defer vaccination until at least about 3 months after chemotherapy ends and immune recovery is confirmed.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Fluorouracil
Questions fréquentes
Can I take Adenovirus types 4 and 7 live with Fluorouracil?
MediHelp rates the interaction as major. Adenovirus types 4 and 7 live and Fluorouracil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluorouracil causes myelosuppression and immunosuppression, so a live oral adenovirus vaccine may replicate excessively and cause disease. The vaccine response may also be blunted.
How serious is the interaction between Adenovirus types 4 and 7 live and Fluorouracil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give the live vaccine during chemotherapy; defer vaccination until at least about 3 months after chemotherapy ends and immune recovery is confirmed.
What other medicines interact with Fluorouracil?
MediHelp also lists interactions of Fluorouracil with, for example, Axicabtagene ciloleucel, Belatacept, Brexucabtagene autoleucel. The full list is on the Fluorouracil page.
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