Interactions médicamenteuses
Deferiprone + Fluorouracil
Gravité: Majeure
Deferiprone and Fluorouracil: major interaction.
Dernière mise à jour
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Résumé
Fluorouracil is myelosuppressive and deferiprone carries a risk of agranulocytosis. Combined use may produce profound neutropenia and serious infections.
Ce que signifie cette interaction, en termes simples
Deferiprone and Fluorouracil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferiprone belongs to Miscellaneous; Fluorouracil belongs to Oncology.
Pourquoi elle survient
Additive bone marrow toxicity affecting neutrophils.
Conduite à tenir
Avoid combining if possible. If unavoidable, increase the frequency of absolute neutrophil count monitoring and interrupt deferiprone for neutropenia.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Fluorouracil
Autres interactions de Deferiprone
- Clozapine + Deferiprone Contre-indiquée
- Abemaciclib + Deferiprone Majeure
- Acalabrutinib + Deferiprone Majeure
- Ado-trastuzumab emtansine + Deferiprone Majeure
- Ado-trastuzumab + Deferiprone Majeure
- Aldesleukin + Deferiprone Majeure
Questions fréquentes
Can I take Deferiprone with Fluorouracil?
MediHelp rates the interaction as major. Deferiprone and Fluorouracil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluorouracil is myelosuppressive and deferiprone carries a risk of agranulocytosis. Combined use may produce profound neutropenia and serious infections.
How serious is the interaction between Deferiprone and Fluorouracil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining if possible. If unavoidable, increase the frequency of absolute neutrophil count monitoring and interrupt deferiprone for neutropenia.
What other medicines interact with Fluorouracil?
MediHelp also lists interactions of Fluorouracil with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Fluorouracil page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
