Interactions médicamenteuses
Ado-trastuzumab + Rozanolixizumab
Gravité: Modérée
Ado-trastuzumab and Rozanolixizumab: moderate interaction.
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Résumé
Rozanolixizumab blocks the neonatal Fc receptor, which lowers circulating IgG levels. Ado-trastuzumab emtansine is an IgG1 antibody conjugate, so its exposure and efficacy could theoretically be reduced.
Ce que signifie cette interaction, en termes simples
Ado-trastuzumab and Rozanolixizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ado-trastuzumab belongs to Oncology; Rozanolixizumab belongs to Miscellaneous.
Pourquoi elle survient
FcRn blockade increases catabolism of IgG-based therapeutics such as trastuzumab emtansine.
Conduite à tenir
Monitor for reduced response to trastuzumab emtansine. Time rozanolixizumab cycles away from treatment where possible, or consider alternatives.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Ado-trastuzumab
- Ado-trastuzumab + Atazanavir Majeure
- Ado-trastuzumab + Baricitinib Majeure
- Ado-trastuzumab + Ceritinib Majeure
- Ado-trastuzumab + Clarithromycin Majeure
- Ado-trastuzumab + Cobicistat Majeure
- Ado-trastuzumab + Conivaptan Majeure
Autres interactions de Rozanolixizumab
- Rozanolixizumab + Upadacitinib Majeure
- Abatacept + Rozanolixizumab Modérée
- Adalimumab + Rozanolixizumab Modérée
- Basiliximab + Rozanolixizumab Modérée
- Bevacizumab + Rozanolixizumab Modérée
- Denosumab + Rozanolixizumab Modérée
Questions fréquentes
Can I take Ado-trastuzumab with Rozanolixizumab?
MediHelp rates the interaction as moderate. Ado-trastuzumab and Rozanolixizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rozanolixizumab blocks the neonatal Fc receptor, which lowers circulating IgG levels. Ado-trastuzumab emtansine is an IgG1 antibody conjugate, so its exposure and efficacy could theoretically be reduced.
How serious is the interaction between Ado-trastuzumab and Rozanolixizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced response to trastuzumab emtansine. Time rozanolixizumab cycles away from treatment where possible, or consider alternatives.
What other medicines interact with Ado-trastuzumab?
MediHelp also lists interactions of Ado-trastuzumab with, for example, Atazanavir, Baricitinib, Ceritinib. The full list is on the Ado-trastuzumab page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
