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Interactions médicamenteuses

Rozanolixizumab + Upadacitinib

Gravité: Majeure

Rozanolixizumab and Upadacitinib: major interaction.

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Résumé

Upadacitinib is a JAK inhibitor that suppresses immune signaling, while rozanolixizumab lowers circulating IgG by blocking the neonatal Fc receptor. Used together, the reduced IgG and impaired cellular immunity may raise the risk of serious infections.

Ce que signifie cette interaction, en termes simples

Rozanolixizumab and Upadacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Rozanolixizumab belongs to Miscellaneous; Upadacitinib belongs to Musculoskeletal.

Niveau de preuve: Low

Pourquoi elle survient

Additive immunosuppression through JAK inhibition and FcRn-mediated IgG reduction.

Conduite à tenir

Avoid combining where possible; if both are necessary, screen for active infection beforehand and monitor closely for signs of infection. Interrupt therapy if a serious infection develops.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Rozanolixizumab with Upadacitinib?

MediHelp rates the interaction as major. Rozanolixizumab and Upadacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Upadacitinib is a JAK inhibitor that suppresses immune signaling, while rozanolixizumab lowers circulating IgG by blocking the neonatal Fc receptor. Used together, the reduced IgG and impaired cellular immunity may raise the risk of serious infections.

How serious is the interaction between Rozanolixizumab and Upadacitinib?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if both are necessary, screen for active infection beforehand and monitor closely for signs of infection. Interrupt therapy if a serious infection develops.

What other medicines interact with Upadacitinib?

MediHelp also lists interactions of Upadacitinib with, for example, Abrocitinib, Adenovirus types 4 and 7 live, Baricitinib. The full list is on the Upadacitinib page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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