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Interactions médicamenteuses

Allopurinol + Amlodipine-benazepril

Gravité: Modérée

Allopurinol and Amlodipine-benazepril: moderate interaction.

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Résumé

Case reports suggest ACE inhibitors given with allopurinol may increase the risk of hypersensitivity reactions, including serious skin reactions. The evidence is limited, but the reactions can be severe.

Ce que signifie cette interaction, en termes simples

Allopurinol and Amlodipine-benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Allopurinol belongs to Genitourinary; Amlodipine-benazepril belongs to Cardiovascular.

Niveau de preuve: Low

Pourquoi elle survient

The mechanism is not established; an additive predisposition to hypersensitivity has been proposed.

Conduite à tenir

Monitor for rash, fever and other hypersensitivity signs, especially early in therapy and in renal impairment. Stop allopurinol promptly if a rash appears.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Allopurinol with Amlodipine-benazepril?

MediHelp rates the interaction as moderate. Allopurinol and Amlodipine-benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Case reports suggest ACE inhibitors given with allopurinol may increase the risk of hypersensitivity reactions, including serious skin reactions. The evidence is limited, but the reactions can be severe.

How serious is the interaction between Allopurinol and Amlodipine-benazepril?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for rash, fever and other hypersensitivity signs, especially early in therapy and in renal impairment. Stop allopurinol promptly if a rash appears.

What other medicines interact with Amlodipine-benazepril?

MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.

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