Interactions médicamenteuses
Allopurinol + Amlodipine-perindopril
Gravité: Modérée
Allopurinol and Amlodipine-perindopril: moderate interaction.
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Résumé
ACE inhibitors given with allopurinol have been associated with hypersensitivity reactions, including rare severe skin reactions. The evidence is limited to case reports and the mechanism is unclear.
Ce que signifie cette interaction, en termes simples
Allopurinol and Amlodipine-perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Allopurinol belongs to Genitourinary; Amlodipine-perindopril belongs to Cardiovascular.
Pourquoi elle survient
The mechanism is not established; an additive hypersensitivity or immune-mediated effect has been proposed.
Conduite à tenir
Counsel patients to report rash, fever or mucosal lesions promptly and stop allopurinol if these occur. Monitor renal function, as allopurinol dose may need adjustment.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contre-indiquée
- Amlodipine-perindopril + Protein a column Contre-indiquée
- Amlodipine-perindopril + Sacubitril / valsartan Contre-indiquée
- Amifostine + Amlodipine-perindopril Majeure
- Amiloride + Amlodipine-perindopril Majeure
- Amlodipine-perindopril + Azilsartan Majeure
Autres interactions de Allopurinol
- Allopurinol + Azathioprine Majeure
- Allopurinol + Didanosine Majeure
- Allopurinol + Mercaptopurine Majeure
- Allopurinol + Pexidartinib Majeure
- Allopurinol + Amlodipine-benazepril Modérée
- Allopurinol + Amoxicillin-clavulanic acid Modérée
Questions fréquentes
Can I take Allopurinol with Amlodipine-perindopril?
MediHelp rates the interaction as moderate. Allopurinol and Amlodipine-perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors given with allopurinol have been associated with hypersensitivity reactions, including rare severe skin reactions. The evidence is limited to case reports and the mechanism is unclear.
How serious is the interaction between Allopurinol and Amlodipine-perindopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report rash, fever or mucosal lesions promptly and stop allopurinol if these occur. Monitor renal function, as allopurinol dose may need adjustment.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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