Interactions médicamenteuses
Aluminum hydroxide + Pamidronate
Gravité: Modérée
Aluminum hydroxide and Pamidronate: moderate interaction.
Dernière mise à jour
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
Résumé
Oral pamidronate is poorly absorbed, and polyvalent cations such as aluminum bind bisphosphonates in the gut, reducing absorption further. This could reduce efficacy of oral therapy. Intravenous pamidronate is not affected.
Ce que signifie cette interaction, en termes simples
Aluminum hydroxide and Pamidronate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aluminum hydroxide belongs to Gastrointestinal Tract; Pamidronate belongs to Musculoskeletal.
Pourquoi elle survient
Aluminum ions chelate the bisphosphonate in the gastrointestinal lumen, forming poorly absorbed complexes.
Conduite à tenir
Separate oral pamidronate from aluminum antacids by at least 2 hours, preferably longer. Use intravenous administration if separation is not feasible.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Réservé aux membres Pro+
Débloquer la page complète
Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Aluminum hydroxide et Pamidronate, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Essayez Pro+ gratuitement pendant 7 jours sur le web. Sans carte.
Autres interactions de Aluminum hydroxide
Autres interactions de Pamidronate
- Dichlorphenamide + Pamidronate Modérée
- Foscarnet + Pamidronate Modérée
- Pamidronate + Tenofovir df Modérée
- Pamidronate + Tenofovir disoproxil Modérée
- Calcium carbonate + Pamidronate Mineure
- Calcium + Pamidronate Mineure
Questions fréquentes
Can I take Aluminum hydroxide with Pamidronate?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Pamidronate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral pamidronate is poorly absorbed, and polyvalent cations such as aluminum bind bisphosphonates in the gut, reducing absorption further. This could reduce efficacy of oral therapy. Intravenous pamidronate is not affected.
How serious is the interaction between Aluminum hydroxide and Pamidronate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate oral pamidronate from aluminum antacids by at least 2 hours, preferably longer. Use intravenous administration if separation is not feasible.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
