Interactions médicamenteuses
Alvimopan + Fentanyl
Gravité: Contre-indiquée
Alvimopan and Fentanyl: contraindicated interaction.
Dernière mise à jour
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Résumé
Alvimopan antagonises peripheral mu-opioid receptors, and patients who have recently taken opioids for more than 7 days are more sensitive to it. This can cause abdominal pain, nausea, vomiting and diarrhea. Short-term perioperative opioid exposure is not expected to cause a significant interaction.
Ce que signifie cette interaction, en termes simples
Alvimopan and Fentanyl are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Competitive antagonism of peripheral mu-opioid receptors by alvimopan.
Conduite à tenir
Do not use alvimopan in patients who have had therapeutic opioid doses for more than 7 consecutive days before starting it. Short-term perioperative use is acceptable.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Fentanyl
- Fentanyl + Isocarboxazid Contre-indiquée
- Fentanyl + Olanzapine / samidorphan Contre-indiquée
- Fentanyl + Phenelzine Contre-indiquée
- Fentanyl + Tranylcypromine Contre-indiquée
- Alfentanil + Fentanyl Majeure
- Alprazolam + Fentanyl Majeure
Questions fréquentes
Can I take Alvimopan with Fentanyl?
MediHelp rates the interaction as contraindicated. Alvimopan and Fentanyl are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Alvimopan antagonises peripheral mu-opioid receptors, and patients who have recently taken opioids for more than 7 days are more sensitive to it. This can cause abdominal pain, nausea, vomiting and diarrhea. Short-term perioperative opioid exposure is not expected to cause a significant interaction.
How serious is the interaction between Alvimopan and Fentanyl?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use alvimopan in patients who have had therapeutic opioid doses for more than 7 consecutive days before starting it. Short-term perioperative use is acceptable.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Fentanyl page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
