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Interactions médicamenteuses

Fentanyl + Phenelzine

Gravité: Contre-indiquée

Fentanyl and Phenelzine: contraindicated interaction.

Dernière mise à jour

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Résumé

Phenelzine irreversibly blocks MAO-A and MAO-B, and fentanyl is a serotonergic opioid. Serotonin syndrome or an excitatory/depressive MAOI-opioid reaction (hypertension or profound respiratory depression) may result.

Ce que signifie cette interaction, en termes simples

Fentanyl and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Fentanyl belongs to Musculoskeletal; Phenelzine belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

MAO inhibition with serotonergic opioid effect

Conduite à tenir

Avoid fentanyl within 14 days of an MAOI; if opioid is essential, use the lowest dose with close monitoring.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Fentanyl with Phenelzine?

MediHelp rates the interaction as contraindicated. Fentanyl and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenelzine irreversibly blocks MAO-A and MAO-B, and fentanyl is a serotonergic opioid. Serotonin syndrome or an excitatory/depressive MAOI-opioid reaction (hypertension or profound respiratory depression) may result.

How serious is the interaction between Fentanyl and Phenelzine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid fentanyl within 14 days of an MAOI; if opioid is essential, use the lowest dose with close monitoring.

What other medicines interact with Fentanyl?

MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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