Interactions médicamenteuses
Amikacin + Atracurium
Gravité: Majeure
Amikacin and Atracurium: major interaction.
Dernière mise à jour
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Résumé
Aminoglycosides have intrinsic neuromuscular blocking activity and can potentiate nondepolarising blockers. This can prolong paralysis and delay recovery of spontaneous breathing, with a risk of respiratory depression or apnoea.
Ce que signifie cette interaction, en termes simples
Amikacin and Atracurium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amikacin belongs to Anti Bacterial; Atracurium belongs to Musculoskeletal.
Pourquoi elle survient
Aminoglycoside reduction of presynaptic acetylcholine release and postsynaptic sensitivity, additive to nondepolarising blockade.
Conduite à tenir
Monitor neuromuscular function with train-of-four and reduce atracurium doses as needed. Ensure ventilatory support is available and recovery is complete before extubation.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Atracurium
- Atracurium + Bacitracin-neomycin-polymyxin Majeure
- Atracurium + Benzhydrocodone / acetaminophen Majeure
- Atracurium + Capreomycin Majeure
- Atracurium + Clindamycin Majeure
- Atracurium + Colistin Majeure
- Atracurium + Fentanyl intranasal Majeure
Autres interactions de Amikacin
- Amikacin + Cidofovir Contre-indiquée
- Adefovir + Amikacin Majeure
- Amikacin + Amphotericin b Majeure
- Amikacin + Amphotericin b deoxycholate Majeure
- Amikacin + Bacitracin Majeure
- Amikacin + Bumetanide Majeure
Questions fréquentes
Can I take Amikacin with Atracurium?
MediHelp rates the interaction as major. Amikacin and Atracurium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Aminoglycosides have intrinsic neuromuscular blocking activity and can potentiate nondepolarising blockers. This can prolong paralysis and delay recovery of spontaneous breathing, with a risk of respiratory depression or apnoea.
How serious is the interaction between Amikacin and Atracurium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with train-of-four and reduce atracurium doses as needed. Ensure ventilatory support is available and recovery is complete before extubation.
What other medicines interact with Atracurium?
MediHelp also lists interactions of Atracurium with, for example, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen, Capreomycin. The full list is on the Atracurium page.
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