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Interactions médicamenteuses

Atracurium + Capreomycin

Gravité: Majeure

Atracurium and Capreomycin: major interaction.

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Résumé

Capreomycin has its own neuromuscular blocking activity and can potentiate and prolong the effect of atracurium. This may result in prolonged paralysis and respiratory failure.

Ce que signifie cette interaction, en termes simples

Atracurium and Capreomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive nondepolarizing-type neuromuscular blockade from capreomycin at the neuromuscular junction.

Conduite à tenir

Avoid if possible; otherwise reduce the atracurium dose and monitor with train-of-four, with ventilatory support available until full recovery.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Atracurium with Capreomycin?

MediHelp rates the interaction as major. Atracurium and Capreomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Capreomycin has its own neuromuscular blocking activity and can potentiate and prolong the effect of atracurium. This may result in prolonged paralysis and respiratory failure.

How serious is the interaction between Atracurium and Capreomycin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise reduce the atracurium dose and monitor with train-of-four, with ventilatory support available until full recovery.

What other medicines interact with Atracurium?

MediHelp also lists interactions of Atracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Atracurium page.

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