Interactions médicamenteuses
Amikacin + Cefotaxime
Gravité: Modérée
Amikacin and Cefotaxime: moderate interaction.
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Résumé
Concurrent use of a cephalosporin with an aminoglycoside has been associated with additive kidney injury in some reports, particularly in patients with other risk factors. Aminoglycoside ototoxicity may also be a concern.
Ce que signifie cette interaction, en termes simples
Amikacin and Cefotaxime can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Cefotaxime belongs to Anti Bacterial.
Pourquoi elle survient
Additive nephrotoxic potential, with aminoglycoside tubular toxicity possibly being aggravated by cephalosporins.
Conduite à tenir
Monitor serum creatinine and amikacin levels during combined therapy, and keep the aminoglycoside course as short as possible. Maintain hydration and avoid other nephrotoxins.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Cefotaxime
- Cefotaxime + Typhoid vaccine live Majeure
- Cefotaxime + Cholera vaccine Modérée
- Cefotaxime + Dexamethasone-tobramycin Modérée
- Cefotaxime + Gentamicin Modérée
- Cefotaxime + Kanamycin Modérée
- Cefotaxime + Microbiota Modérée
Autres interactions de Amikacin
- Amikacin + Cidofovir Contre-indiquée
- Adefovir + Amikacin Majeure
- Amikacin + Amphotericin b Majeure
- Amikacin + Amphotericin b deoxycholate Majeure
- Amikacin + Atracurium Majeure
- Amikacin + Bacitracin Majeure
Questions fréquentes
Can I take Amikacin with Cefotaxime?
MediHelp rates the interaction as moderate. Amikacin and Cefotaxime can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use of a cephalosporin with an aminoglycoside has been associated with additive kidney injury in some reports, particularly in patients with other risk factors. Aminoglycoside ototoxicity may also be a concern.
How serious is the interaction between Amikacin and Cefotaxime?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and amikacin levels during combined therapy, and keep the aminoglycoside course as short as possible. Maintain hydration and avoid other nephrotoxins.
What other medicines interact with Cefotaxime?
MediHelp also lists interactions of Cefotaxime with, for example, Typhoid vaccine live, Cholera vaccine, Dexamethasone-tobramycin. The full list is on the Cefotaxime page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
