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Interactions médicamenteuses

Amiodarone + Amisulpride

Gravité: Contre-indiquée

Amiodarone and Amisulpride: contraindicated interaction.

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Résumé

Both drugs prolong the QT interval, and their combination substantially increases the risk of torsades de pointes. Amiodarone's long half-life means the risk persists after it is stopped.

Ce que signifie cette interaction, en termes simples

Amiodarone and Amisulpride are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Amiodarone belongs to Cardiovascular; Amisulpride belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive QT prolongation through blockade of cardiac potassium channels (pharmacodynamic).

Conduite à tenir

Avoid the combination and choose an antipsychotic with lower QT liability. If it cannot be avoided, use continuous ECG monitoring and keep potassium and magnesium normal.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amiodarone with Amisulpride?

MediHelp rates the interaction as contraindicated. Amiodarone and Amisulpride are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and their combination substantially increases the risk of torsades de pointes. Amiodarone's long half-life means the risk persists after it is stopped.

How serious is the interaction between Amiodarone and Amisulpride?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antipsychotic with lower QT liability. If it cannot be avoided, use continuous ECG monitoring and keep potassium and magnesium normal.

What other medicines interact with Amiodarone?

MediHelp also lists interactions of Amiodarone with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Amiodarone page.

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