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Interactions médicamenteuses

Amiodarone + Eliglustat

Gravité: Contre-indiquée

Amiodarone and Eliglustat: contraindicated interaction.

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Résumé

Eliglustat is metabolized by CYP2D6 and CYP3A4, and amiodarone inhibits CYP2D6 and to some degree CYP3A4 and P-gp. Eliglustat exposure rises and may prolong PR, QRS and QT intervals. Both drugs also affect cardiac conduction.

Ce que signifie cette interaction, en termes simples

Amiodarone and Eliglustat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Amiodarone belongs to Cardiovascular; Eliglustat belongs to Miscellaneous.

Niveau de preuve: Moderate

Pourquoi elle survient

Amiodarone inhibits CYP2D6 and CYP3A4, raising eliglustat levels, with additive conduction effects.

Conduite à tenir

Avoid the combination; labeling advises against eliglustat with class Ia and III antiarrhythmics. Use an alternative antiarrhythmic if eliglustat is needed.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amiodarone with Eliglustat?

MediHelp rates the interaction as contraindicated. Amiodarone and Eliglustat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Eliglustat is metabolized by CYP2D6 and CYP3A4, and amiodarone inhibits CYP2D6 and to some degree CYP3A4 and P-gp. Eliglustat exposure rises and may prolong PR, QRS and QT intervals. Both drugs also affect cardiac conduction.

How serious is the interaction between Amiodarone and Eliglustat?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; labeling advises against eliglustat with class Ia and III antiarrhythmics. Use an alternative antiarrhythmic if eliglustat is needed.

What other medicines interact with Amiodarone?

MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.

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