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Interactions médicamenteuses

Amitriptyline + Pimozide

Gravité: Contre-indiquée

Amitriptyline and Pimozide: contraindicated interaction.

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Résumé

Amitriptyline and pimozide each delay ventricular repolarisation, so using them together adds to the chance of marked QTc lengthening. This can precipitate torsades de pointes, particularly with hypokalaemia, bradycardia or structural heart disease.

Ce que signifie cette interaction, en termes simples

Amitriptyline and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Amitriptyline belongs to Central Nervous System; Pimozide belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive QTc prolongation through hERG potassium channel blockade

Conduite à tenir

Do not co-prescribe; choose an agent without QT liability. If one must continue, obtain ECG and electrolytes first.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amitriptyline with Pimozide?

MediHelp rates the interaction as contraindicated. Amitriptyline and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Amitriptyline and pimozide each delay ventricular repolarisation, so using them together adds to the chance of marked QTc lengthening. This can precipitate torsades de pointes, particularly with hypokalaemia, bradycardia or structural heart disease.

How serious is the interaction between Amitriptyline and Pimozide?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-prescribe; choose an agent without QT liability. If one must continue, obtain ECG and electrolytes first.

What other medicines interact with Amitriptyline?

MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.

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