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Interactions médicamenteuses

Amitriptyline + Procarbazine

Gravité: Contre-indiquée

Amitriptyline and Procarbazine: contraindicated interaction.

Dernière mise à jour

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Résumé

Amitriptyline blocks reuptake of serotonin and noradrenaline while procarbazine stops their breakdown. Together they can precipitate serotonin syndrome or a hypertensive crisis.

Ce que signifie cette interaction, en termes simples

Amitriptyline and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Amitriptyline belongs to Central Nervous System; Procarbazine belongs to Oncology.

Niveau de preuve: High

Pourquoi elle survient

MAO inhibition combined with monoamine reuptake inhibition causes excess synaptic serotonin and noradrenaline

Conduite à tenir

Contraindicated; allow at least 14 days after stopping an irreversible MAOI before starting amitriptyline (and 2 weeks the other way around).

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amitriptyline with Procarbazine?

MediHelp rates the interaction as contraindicated. Amitriptyline and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Amitriptyline blocks reuptake of serotonin and noradrenaline while procarbazine stops their breakdown. Together they can precipitate serotonin syndrome or a hypertensive crisis.

How serious is the interaction between Amitriptyline and Procarbazine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Contraindicated; allow at least 14 days after stopping an irreversible MAOI before starting amitriptyline (and 2 weeks the other way around).

What other medicines interact with Amitriptyline?

MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.

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