Interactions médicamenteuses
Amlodipine-atorvastatin + Danazol
Gravité: Majeure
Amlodipine-atorvastatin and Danazol: major interaction.
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Résumé
Danazol inhibits CYP3A4 and may raise atorvastatin and amlodipine concentrations. Increased atorvastatin exposure raises the risk of myopathy and rhabdomyolysis, and amlodipine excess may cause hypotension or edema.
Ce que signifie cette interaction, en termes simples
Amlodipine-atorvastatin and Danazol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Danazol inhibits CYP3A4, decreasing metabolism of amlodipine and atorvastatin.
Conduite à tenir
Avoid the combination where possible, or use the lowest effective statin dose and monitor for muscle symptoms, CK and blood pressure.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Amlodipine-atorvastatin
Questions fréquentes
Can I take Amlodipine-atorvastatin with Danazol?
MediHelp rates the interaction as major. Amlodipine-atorvastatin and Danazol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Danazol inhibits CYP3A4 and may raise atorvastatin and amlodipine concentrations. Increased atorvastatin exposure raises the risk of myopathy and rhabdomyolysis, and amlodipine excess may cause hypotension or edema.
How serious is the interaction between Amlodipine-atorvastatin and Danazol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use the lowest effective statin dose and monitor for muscle symptoms, CK and blood pressure.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
