Drug interactions
Amlodipine-atorvastatin + Danazol
Severity: Major
Amlodipine-atorvastatin and Danazol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol inhibits CYP3A4 and may raise atorvastatin and amlodipine concentrations. Increased atorvastatin exposure raises the risk of myopathy and rhabdomyolysis, and amlodipine excess may cause hypotension or edema.
What this interaction means in plain words
Amlodipine-atorvastatin and Danazol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Danazol inhibits CYP3A4, decreasing metabolism of amlodipine and atorvastatin.
What to do
Avoid the combination where possible, or use the lowest effective statin dose and monitor for muscle symptoms, CK and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-atorvastatin
Frequently asked questions
Can I take Amlodipine-atorvastatin with Danazol?
MediHelp rates the interaction as major. Amlodipine-atorvastatin and Danazol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Danazol inhibits CYP3A4 and may raise atorvastatin and amlodipine concentrations. Increased atorvastatin exposure raises the risk of myopathy and rhabdomyolysis, and amlodipine excess may cause hypotension or edema.
How serious is the interaction between Amlodipine-atorvastatin and Danazol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use the lowest effective statin dose and monitor for muscle symptoms, CK and blood pressure.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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