Interactions médicamenteuses
Amoxapine + Donepezil
Gravité: Majeure
Amoxapine and Donepezil: major interaction.
Dernière mise à jour
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Résumé
Donepezil has a known risk of QT prolongation and torsades de pointes, and amoxapine, a tricyclic-related antidepressant, can also prolong the QT interval. Combined use may raise arrhythmia risk, especially with electrolyte disturbance or cardiac disease. Amoxapine's anticholinergic activity may also oppose donepezil's cholinergic benefit.
Ce que signifie cette interaction, en termes simples
Amoxapine and Donepezil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Additive QT prolongation, plus pharmacodynamic opposition of cholinesterase inhibition by antimuscarinic effects.
Conduite à tenir
Avoid the combination where possible; if used, obtain a baseline ECG, correct potassium and magnesium, and monitor the QTc. Consider an antidepressant with less QT and anticholinergic liability.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Donepezil
- Donepezil + Dronedarone Contre-indiquée
- Donepezil + Pimozide Contre-indiquée
- Donepezil + Thioridazine Contre-indiquée
- Donepezil + Vandetanib Contre-indiquée
- Amiodarone + Donepezil Majeure
- Amisulpride + Donepezil Majeure
Questions fréquentes
Can I take Amoxapine with Donepezil?
MediHelp rates the interaction as major. Amoxapine and Donepezil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Donepezil has a known risk of QT prolongation and torsades de pointes, and amoxapine, a tricyclic-related antidepressant, can also prolong the QT interval. Combined use may raise arrhythmia risk, especially with electrolyte disturbance or cardiac disease. Amoxapine's anticholinergic activity may also oppose donepezil's cholinergic benefit.
How serious is the interaction between Amoxapine and Donepezil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, obtain a baseline ECG, correct potassium and magnesium, and monitor the QTc. Consider an antidepressant with less QT and anticholinergic liability.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
