Interactions médicamenteuses
Amoxapine + Isocarboxazid
Gravité: Contre-indiquée
Amoxapine and Isocarboxazid: contraindicated interaction.
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Résumé
Combining an MAOI with amoxapine can produce serotonin syndrome and hypertensive reactions. Labeling prohibits concurrent use of MAOIs and tricyclic-type antidepressants.
Ce que signifie cette interaction, en termes simples
Amoxapine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
MAO inhibition combined with amoxapine's reuptake inhibition of norepinephrine and serotonin leads to excess monoamine activity.
Conduite à tenir
Do not coadminister. Allow a washout of at least 14 days after stopping isocarboxazid before starting amoxapine, and an adequate washout in the other direction.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Isocarboxazid
- 5-HTP + Isocarboxazid Contre-indiquée
- Amitriptyline + Isocarboxazid Contre-indiquée
- Amobarbital + Isocarboxazid Contre-indiquée
- Apraclonidine + Isocarboxazid Contre-indiquée
- Atomoxetine + Isocarboxazid Contre-indiquée
- Benzphetamine + Isocarboxazid Contre-indiquée
Questions fréquentes
Can I take Amoxapine with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Amoxapine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining an MAOI with amoxapine can produce serotonin syndrome and hypertensive reactions. Labeling prohibits concurrent use of MAOIs and tricyclic-type antidepressants.
How serious is the interaction between Amoxapine and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Allow a washout of at least 14 days after stopping isocarboxazid before starting amoxapine, and an adequate washout in the other direction.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
