Interactions médicamenteuses
Amoxapine + Thioridazine
Gravité: Contre-indiquée
Amoxapine and Thioridazine: contraindicated interaction.
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Résumé
Both drugs can prolong the QT interval, and thioridazine carries a particularly high risk of torsades de pointes. Combining them also adds anticholinergic and sedative effects, and thioridazine can raise amoxapine levels.
Ce que signifie cette interaction, en termes simples
Amoxapine and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Additive QT prolongation, with thioridazine inhibiting CYP2D6 metabolism of amoxapine.
Conduite à tenir
Avoid combining; choose an antidepressant with minimal QT effect. If previously combined, perform ECG and check electrolytes.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Thioridazine
- Abiraterone + Thioridazine Contre-indiquée
- Adagrasib + Thioridazine Contre-indiquée
- Amiodarone + Thioridazine Contre-indiquée
- Amisulpride + Thioridazine Contre-indiquée
- Amitriptyline + Thioridazine Contre-indiquée
- Anagrelide + Thioridazine Contre-indiquée
Questions fréquentes
Can I take Amoxapine with Thioridazine?
MediHelp rates the interaction as contraindicated. Amoxapine and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs can prolong the QT interval, and thioridazine carries a particularly high risk of torsades de pointes. Combining them also adds anticholinergic and sedative effects, and thioridazine can raise amoxapine levels.
How serious is the interaction between Amoxapine and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; choose an antidepressant with minimal QT effect. If previously combined, perform ECG and check electrolytes.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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