Drug interactions
Amoxapine + Thioridazine
Severity: Contraindicated
Amoxapine and Thioridazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and thioridazine carries a particularly high risk of torsades de pointes. Combining them also adds anticholinergic and sedative effects, and thioridazine can raise amoxapine levels.
What this interaction means in plain words
Amoxapine and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive QT prolongation, with thioridazine inhibiting CYP2D6 metabolism of amoxapine.
What to do
Avoid combining; choose an antidepressant with minimal QT effect. If previously combined, perform ECG and check electrolytes.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Anagrelide + Thioridazine Contraindicated
Frequently asked questions
Can I take Amoxapine with Thioridazine?
MediHelp rates the interaction as contraindicated. Amoxapine and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs can prolong the QT interval, and thioridazine carries a particularly high risk of torsades de pointes. Combining them also adds anticholinergic and sedative effects, and thioridazine can raise amoxapine levels.
How serious is the interaction between Amoxapine and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; choose an antidepressant with minimal QT effect. If previously combined, perform ECG and check electrolytes.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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