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Interactions médicamenteuses

Amphotericin b + Colistin

Gravité: Majeure

Amphotericin b and Colistin: major interaction.

Dernière mise à jour

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Résumé

Both agents are nephrotoxic, and colistin also carries neurotoxicity risk. Together the risk of acute kidney injury is higher, and reduced colistin clearance can worsen toxicity.

Ce que signifie cette interaction, en termes simples

Amphotericin b and Colistin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Amphotericin b belongs to Anti Fungals; Colistin belongs to Anti Bacterial.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive direct tubular nephrotoxicity.

Conduite à tenir

Avoid concurrent use if an alternative antifungal or antibiotic is available, or use a lipid amphotericin formulation. Monitor serum creatinine daily and adjust the colistin dose to renal function.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amphotericin b with Colistin?

MediHelp rates the interaction as major. Amphotericin b and Colistin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents are nephrotoxic, and colistin also carries neurotoxicity risk. Together the risk of acute kidney injury is higher, and reduced colistin clearance can worsen toxicity.

How serious is the interaction between Amphotericin b and Colistin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if an alternative antifungal or antibiotic is available, or use a lipid amphotericin formulation. Monitor serum creatinine daily and adjust the colistin dose to renal function.

What other medicines interact with Amphotericin b?

MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.

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