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Interactions médicamenteuses

Bacitracin + Colistin

Gravité: Majeure

Bacitracin and Colistin: major interaction.

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Résumé

Systemic bacitracin is markedly nephrotoxic, and combining it with colistin compounds the risk of kidney injury. Neurotoxicity and neuromuscular effects may also be additive.

Ce que signifie cette interaction, en termes simples

Bacitracin and Colistin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Bacitracin belongs to Miscellaneous; Colistin belongs to Anti Bacterial.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive nephrotoxicity through renal tubular injury.

Conduite à tenir

Avoid systemic combination; if unavoidable, monitor renal function daily and adjust doses to creatinine clearance.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Bacitracin with Colistin?

MediHelp rates the interaction as major. Bacitracin and Colistin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Systemic bacitracin is markedly nephrotoxic, and combining it with colistin compounds the risk of kidney injury. Neurotoxicity and neuromuscular effects may also be additive.

How serious is the interaction between Bacitracin and Colistin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic combination; if unavoidable, monitor renal function daily and adjust doses to creatinine clearance.

What other medicines interact with Colistin?

MediHelp also lists interactions of Colistin with, for example, Polymyxin b, Amikacin, Amphotericin b deoxycholate. The full list is on the Colistin page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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