Interactions médicamenteuses
Ampicillin + Chloramphenicol
Gravité: Modérée
Ampicillin and Chloramphenicol: moderate interaction.
Dernière mise à jour
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Résumé
Chloramphenicol may antagonize the bactericidal effect of ampicillin, and worse outcomes have been suggested in some serious infections such as meningitis. The data are mostly in vitro or observational.
Ce que signifie cette interaction, en termes simples
Ampicillin and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ampicillin belongs to Anti Bacterial; Chloramphenicol belongs to Anti Bacterial.
Pourquoi elle survient
Pharmacodynamic antagonism: inhibition of bacterial protein synthesis and growth reduces penicillin killing.
Conduite à tenir
Avoid the combination in meningitis, endocarditis and other infections requiring bactericidal therapy; choose one active agent based on susceptibility.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Ampicillin
- Allopurinol + Ampicillin Modérée
- Ampicillin + Bcg vaccine live Modérée
- Ampicillin + Chloroquine Modérée
- Ampicillin + Cholera vaccine Modérée
- Ampicillin + Demeclocycline Modérée
- Ampicillin + Eravacycline Modérée
Autres interactions de Chloramphenicol
Questions fréquentes
Can I take Ampicillin with Chloramphenicol?
MediHelp rates the interaction as moderate. Ampicillin and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol may antagonize the bactericidal effect of ampicillin, and worse outcomes have been suggested in some serious infections such as meningitis. The data are mostly in vitro or observational.
How serious is the interaction between Ampicillin and Chloramphenicol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in meningitis, endocarditis and other infections requiring bactericidal therapy; choose one active agent based on susceptibility.
What other medicines interact with Ampicillin?
MediHelp also lists interactions of Ampicillin with, for example, Allopurinol, Bcg vaccine live, Chloroquine. The full list is on the Ampicillin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
