Interactions médicamenteuses
Allopurinol + Ampicillin
Gravité: Modérée
Allopurinol and Ampicillin: moderate interaction.
Dernière mise à jour
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Résumé
Patients taking allopurinol together with ampicillin have a higher reported frequency of skin rash than those taking either drug alone. The rash is generally mild and may be hard to tell apart from allopurinol hypersensitivity, which can occasionally be serious.
Ce que signifie cette interaction, en termes simples
Allopurinol and Ampicillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Allopurinol belongs to Genitourinary; Ampicillin belongs to Anti Bacterial.
Pourquoi elle survient
The mechanism is not established; an additive or synergistic hypersensitivity-type reaction has been proposed.
Conduite à tenir
Counsel the patient to report any rash promptly and evaluate it carefully for allopurinol hypersensitivity. If a rash appears, stop allopurinol and consider an alternative antibiotic.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Allopurinol
- Allopurinol + Azathioprine Majeure
- Allopurinol + Didanosine Majeure
- Allopurinol + Mercaptopurine Majeure
- Allopurinol + Pexidartinib Majeure
- Allopurinol + Amlodipine-benazepril Modérée
- Allopurinol + Amlodipine-perindopril Modérée
Autres interactions de Ampicillin
- Ampicillin + Bcg vaccine live Modérée
- Ampicillin + Chloramphenicol Modérée
- Ampicillin + Chloroquine Modérée
- Ampicillin + Cholera vaccine Modérée
- Ampicillin + Demeclocycline Modérée
- Ampicillin + Eravacycline Modérée
Questions fréquentes
Can I take Allopurinol with Ampicillin?
MediHelp rates the interaction as moderate. Allopurinol and Ampicillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Patients taking allopurinol together with ampicillin have a higher reported frequency of skin rash than those taking either drug alone. The rash is generally mild and may be hard to tell apart from allopurinol hypersensitivity, which can occasionally be serious.
How serious is the interaction between Allopurinol and Ampicillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report any rash promptly and evaluate it carefully for allopurinol hypersensitivity. If a rash appears, stop allopurinol and consider an alternative antibiotic.
What other medicines interact with Allopurinol?
MediHelp also lists interactions of Allopurinol with, for example, Azathioprine, Didanosine, Mercaptopurine. The full list is on the Allopurinol page.
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