Interactions médicamenteuses
Antipsychotics (e.g., haloperidol) + Metoclopramide
Gravité: Majeure
Antipsychotics (e.g., haloperidol) and Metoclopramide: major interaction.
Dernière mise à jour Sources: US FDA label
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Résumé
Combining metoclopramide with antipsychotics increases the risk of extrapyramidal symptoms, including acute dystonia, parkinsonism, akathisia and tardive dyskinesia, and may raise neuroleptic malignant syndrome risk. Metoclopramide labeling warns against use with other dopamine antagonists. Older adults and long-term users are most at risk.
Ce que signifie cette interaction, en termes simples
Antipsychotics (e.g., haloperidol) and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Additive central dopamine D2 receptor antagonism in the nigrostriatal pathway.
Conduite à tenir
Avoid the combination; use a non-dopamine-blocking antiemetic such as ondansetron (checking QT risk) or a prokinetic alternative. If unavoidable, restrict metoclopramide to short courses (under 5 days) and monitor for movement disorders.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Références
Autres interactions de Metoclopramide
- Amantadine + Metoclopramide Majeure
- Amoxapine + Metoclopramide Majeure
- Apomorphine + Metoclopramide Majeure
- Aripiprazole + Metoclopramide Majeure
- Asenapine transdermal + Metoclopramide Majeure
- Asenapine + Metoclopramide Majeure
Questions fréquentes
Can I take Antipsychotics (e.g., haloperidol) with Metoclopramide?
MediHelp rates the interaction as major. Antipsychotics (e.g., haloperidol) and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining metoclopramide with antipsychotics increases the risk of extrapyramidal symptoms, including acute dystonia, parkinsonism, akathisia and tardive dyskinesia, and may raise neuroleptic malignant syndrome risk. Metoclopramide labeling warns against use with other dopamine antagonists. Older adults and long-term users are most at risk.
How serious is the interaction between Antipsychotics (e.g., haloperidol) and Metoclopramide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use a non-dopamine-blocking antiemetic such as ondansetron (checking QT risk) or a prokinetic alternative. If unavoidable, restrict metoclopramide to short courses (under 5 days) and monitor for movement disorders.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Apomorphine. The full list is on the Metoclopramide page.
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