Drug interactions
antipsychotics (e.g., haloperidol) + metoclopramide
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↑ EPS/tardive dyskinesia risk.
Mechanism of action
Additive D2 blockade.
Clinical management
Avoid chronic combined use.
Drug reference
References
Frequently asked questions
Can I take antipsychotics (e.g., haloperidol) with metoclopramide?
The interaction is rated: Major. ↑ EPS/tardive dyskinesia risk.
How serious is the interaction between antipsychotics (e.g., haloperidol) and metoclopramide?
The interaction is rated: Major. Evidence level: Moderate.
How is the interaction between antipsychotics (e.g., haloperidol) and metoclopramide managed?
Avoid chronic combined use.
Why do antipsychotics (e.g., haloperidol) and metoclopramide interact?
Additive D2 blockade.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.